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Prof. Dr.

Ole Holger Petersen

Wahljahr: 2010
Sektion: Physiologie und Pharmakologie/Toxikologie
Stadt: Cardiff
Land: Großbritannien
CV Ole Holger Petersen - Englisch (pdf)

Forschung

Ole Petersen is distinguished for studies - carried out during his 28 years in the George Holt Chair of Physiology at Liverpool University - revealing the mechanisms by which secretion from exocrine glands are controlled. He pioneered single channel current recording in epithelial cells, characterizing several types of calcium-activated ion channels important for fluid secretion. He discovered hormone-evoked local calcium signals and showed that they controlled both fluid and enzyme secretion.

More recently, in work continuing at Cardiff University’s School of Biosciences, he has discovered how certain alcohol metabolites evoke excessive calcium release from intracellular stores thereby initiating pancreatitis, a human disease in which the pancreas digests itself and its surroundings. He has defined the intracellular receptor mechanisms responsible for alcohol-related pancreatitis and shown how they can be blocked.

First single channel current recordings in epithelial cells (Petersen & Maruyama Nature 1984). Discovered local Ca2+ signals in epithelial cells (Thorn, …., Petersen Cell 1993), Ca2+ release from nuclear envelope (Gerasimenko,…, Petersen Cell 1995), intracellular Ca2+ tunnels (Mogami,.., Petersen Cell 1997), role of IP3 receptors in alcohol-related pancreatitis (Gerasimenko, ..., Petersen PNAS 2009) and CRAC channel blockade as treatment for pancreatitis (Gerasimenko,…., Petersen PNAS 2013). Discovery of bradykinin-evoked calcium signals in pancreatic stellate cells (Gryshchenko,…, Petersen J Physiol 2016).

Career

  • since 2017 Professor of Physiology and Director of the Academia Europaea – Cardiff Knowledge Hub, Cardiff School of Biosciences, Cardiff University, Wales, UK
  • 2010-2017 Medical Research Council Professor at Cardiff School of Biosciences, Cardiff University, Wales, UK
  • 2010-2015 Director and Head of Cardiff School of Biosciences, Cardiff University, Wales, UK
  • 1998-2009 Medical Research Council Professor at the University of Liverpool, England, UK
  • 1981-2009 George Holt Professor of Physiology at the University of Liverpool, England, UK
  • 1981-1998 Chairman of Department of Physiology, University of Liverpool, England, UK
  • 1975-1981 Symers Professor of Physiology at the University of Dundee, Scotland, UK
  • 1972 Habilitation (Dr. Med.) University of Copenhagen, Denmark
  • 1969 Promotion (Cand. Med. [MBChB]) University of Copenhagen, Denmark
  • 1961-1969 Medical student at University of Copenhagen, Denmark

Functions

  • since 2016 Member of the SAPEA (Science Advice for Policy by European Academies) Board (part of the European Commission’s SAM (Science Advice Mechanism)
  • since 2016 Vice-President and Treasurer of Academia Europaea
  • 2016-2019 Member of the Royal Society’s Sectional Committee for Anatomy, Physiology and Neurosciences
  • 2015-2016 Vice-President of Academia Europaea, Chair of Life Sciences Class
  • since 2014 The Academy of Medical Sciences’ Champion for Wales
  • since 2013 The Royal Society’s representative on EASAC’s Biosciences Steering Panel
  • 2010-2015 Chair of the Biological Sciences Sub-panel for the UK Government’s (Higher Education Funding Council) Research Excellence Framework 2014 (REF2014) and also Member of Main Panel A
  • 2010-2013 Member of The Royal Society’s Sectional Committee for Anatomy, Physiology and Neurosciences
  • 2010-2019 Member of the Welsh Government’s Science Advisory Council for Wales
  • 2008-2011 Chair of the European Research Council’s (ERC) Starting Grant Panel for Physiology, Pathophysiology and Endocrinology
  • since 2008 Member of Academia Europaea’s Executive Board and Council
  • 2006-2008 President of The Physiological Society (UK)
  • 2005-2006 Vice-President of The Royal Society
  • 2004-2006 Member of The Royal Society’s Council
  • 1995-2014 Chair of Academia Europaea’s Nominations Sub-Committee

Honours and Memberships

  • 2018 Elected the American Physiological Society’s Walter B Cannon Memorial Award Lecturer. The Plenary Award Lecture to be delivered at Experimental Biology in San Diego, USA on 22nd April 2018
  • 2017 Elected Honorary Member of the German Society for Gastroenterology, Digestive and Metabolic Diseases. Award Lecture delivered at 72nd Annual Meeting of the Society in Dresden on 14th September 2017
  • 2015 Elected Honorary Member of The Physiological Society (UK)
  • 2014 Festschrift for Ole Petersen,  J. Physiol.  592, 259-312, 2014
  • 2013 The American Physiological Society’s Horace W Davenport Distinguished Lectureship. Award Lecture delivered at FASEB’s ‘Experimental Biology 2013’, Boston, MA, USA
  • 2013 Honorary President and Keynote Lecturer at  the 37th International Congress of Physiological Sciences (IUPS), Birmingham, England, UK
  • since 2010 Member of the German National Academy of Sciences Leopoldina (ML)
  • 2010 Lifetime Achievement Award, European Pancreatic Club
  • 2008 Appointed Commander of the Order of the British Empire (CBE) by Queen Elizabeth II for ‘Services to Science’
  • 2004 Honorary Member of the Hungarian Academy of Sciences
  • 2003 J.E. Purkyne Honorary Medal for ‘Merit in the Biological Sciences’ from the Academy of Sciences of the Czech Republic
  • 2001 Fellow of the Royal College of Physicians London (FRCP)
  • 2000 Fellow of The Royal Society (FRS)
  • 1998 Fellow of the Academy of Medical Sciences (UK)
  • 1994 Nordic Insulin Foundation’s H.C. Jacobaeus Prize and Lectureship. Award Lecture delivered at the Royal Danish Academy of Sciences & Letters, Copenhagen, Denmark
  • 1991 The Physiological Society’s Annual Review Prize and Lectureship. Award Lecture delivered at the University of Cambridge, England, UK. (Lecture published in  J. Physiol. 448, 1-51, 1992
  • 1993 The article ‘Calcium-activated potassium channels and their role in secretion’ by Ole Petersen and Yoshio Maruyama (published in Nature 307, 693-696, 1984) named as an ISI Citation Classic (Current Contents, Life Sciences vol. 36, no. 48, p.9)
  • since 1988 Foreign Member of the Royal Danish Academy of Sciences & Letters
  • since 1988 Member of Academia Europaea

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