|Wahljahr:||2003||Sektion:||Mikrobiologie und Immunologie|
CV Tasuku Honjo - English (pdf)
Tasuku Honjo is well known for his discovery of activation-induced cytidine deaminase (AID) that is essential for class switch recombination and somatic hypermutation. AID is the enzyme that engraves antibody memory on the genome. He has established the basic conceptual framework of class switch recombination starting from discovery of DNA deletion (1978) and S regions (1980), followed by elucidation of the whole mouse immunoglobulin heavy-chain locus. His contribution further extended to cDNA cloning of IL-4 and IL-5 cytokines involved in class switching and IL-2 receptor alpha chain. Aside from class switching recombination, he discovered PD-1 (program cell death 1), a negative coreceptor at the effector phase of immune response and showed that PD-1 modulation contributes to treatments of viral infection, tumor and autoimmunity. In addition, he is known to be a discoverer of RBP-J, a nuclear protein that interacts with the intracellular domain of Notch in the nucleus. Notch/RBP-J signaling has been shown to regulate a variety of cell lineage commitment including T and B cells.
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