|Sektion:||Mikrobiologie und Immunologie|
CV Volkmar Braun - Englisch (pdf)
Volkmar Braun made major contributions to the understanding of bacterial outer membrane structure and function. He discovered and characterized the first lipoprotein with covalently linked lipid which became a model protein for the study of protein secretion and activation of the immune system. He discovered and characterized multifunctional outer membrane proteins which serve as receptors for viruses and protein toxins and which are energy-coupled transporters for iron complexes. Transport requires a novel transfer of energy from the cytoplasmic membrane into the outer membrane and is regulated by a novel transmembrane transcription control.
His work explains how bacteria cope with the extreme iron deficiency in the human host. Iron transport systems contribute to the virulence of pathogens. Furthermore, his work contributed substantially to the knowledge of the import, export and mode of action of bacterial protein toxins. He showed that the diversity of these toxins is derived from the genetic exchange of DNA fragments that precisely encode functional domains.
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