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Prof. Dr.

Franz Oesch

Year of election: 1999
Section: Physiology and Pharmacology/Toxicology
City: Wackernheim
Country: Germany
CV Franz Oesch - Englisch (pdf)

Research

Hauptarbeitsgebiete: Isolierung und Charakterisierung der bei der metabolischen Aktivierung potentieller Kanzerogene beteiligten Enzyme aus verschiedenen Spezies (z. B. mikrosomale Epoxidhydrolase, Dihydrodioldehydrogenase, Glutathion-S-Transferasen; Isolation, physikochemische und biochemische Charakterisierung solcher Enzyme, Untersuchungen zum Einfluss dieser Enzyme auf die Kontrolle reaktiver Stoffwechselprodukte); Mutagenität (quantitative Erfassung des Einflusses verschiedener Enzyme auf die Kontrolle reaktiver Stoffwechselprodukte); Testsysteme und ihre Aussagekraft; Studium der metabolischen Aktivierung (u. a. von Metaboliten des Benzo(a)pyrens); Regulation der Aktivität von Cytochrom-P-450-Isoenzymen (spezifische Phosphorylierung, Einfluss verschiedener Nahrungskomponenten); Kompartimentierung von Zellen und deren Konsequenzen für gentoxische Risiken; biochemische Basis der Kanzerogenese (neue Wege des Metabolismus, neue karzinogene Metaboliten; Veränderung der Expression kanzerogenmetabolisierender Enzyme; Auslösung von Krebs durch nicht-gentoxische Stoffe, u. a. Lipidsenker; Studium von Zellmembrankomponenten, die die normale Zellproliferation kontrollieren)

Career

  • since 1981 Professor (C4) of Pharmacology and Toxicology, University of Mainz, Germany
  • 1983-2004 Director, Institute of Toxicology, University of Mainz, Germany
  • 1981-1983 Chairman, Department of Molecular Pharmacology, University of Mainz, Germany
  • 1974-1981 Professor (C3) of Pharmacology and Toxicology; Head, Section on Molecular Pharmacology, University of Mainz, Germany
  • 1973 Habilitation at the University Basel, Switzerland; PD for Pharmacology and Toxicology, University of Basel, Switzerland
  • 1972-1974 Senior Research Associate, Department of Pharmacology, Biocenter of the University of Basel, Switzerland
  • 1969-1971 Fellow of the Visiting Program of the US Health Service, NIAMD, National Institutes of Health, Bethesda, USA
  • 1965-1969 Junior (65-66), then Senior (66-69) Assistant at the University of Fribourg, Switzerland
  • 1969 Promotion an der Universität Fribourg, Switzerland; Ph.D., University of Fribourg, Switzerland
  • 1961-1969 Studies of Chemistry and Biology at the University Fribourg, Switzerland

Projects

  • 2003-2004 Chairman of the Research Group „Susceptibility factors of tumorigenesis“
  • 1996-2002 Chairman of the Center Grant „Organ and cell type specificity of tumorigenesis“
  • 1984-1995 Chairman of the Center Grant SFB 302 „Control factors of tumorigenesis“

Honours and Memberships

  • 2012 Poulsson Medal and Annual Lecture Award of the Norwegian Society of Pharmacology  and Toxicology
  • 2008 Election to the National Academy of Medicine of France
  • 2002 Salk Lecture, Salk Institute, La Jolla, USA
  • 2000 Werner Heisenberg-Medaille
  • 2000 Gerhard Zbinden Memorial Lecture Award
  • 1999 Prize for Scientific Innovation of the State Rheinland-Pfalz , Germany
  • 1999 Election to the National Academy of Sciences of Germany Leopoldina
  • 1998 Keynote Review, International EAPCCT Congress, Zurich, Switzerland
  • 1998 Keynote Lecture, European Workshop on Drug Metabolism, Kopenhagen, Denmark
  • 1997 IEM Lecture, Karolinska Institute, Stockholm, Sweden
  • 1996 International Union Against Cancer Roll of Honour
  • 1995 MDC-Lecture, Max Delbrück Centrum für Molekulare Medizin, Berlin, Germany
  • 1994 Novum Lecture, Karolinska Institute, Novum-Stockholm, Sweden
  • 1993 International Society for the Study of Xenobiotics Award
  • 1992 Otto Warburg Memorial Lecture, Berlin, Germany
  • 1992 Election to the Academia Europea
  • 1991 Keynote Lecture, International ISSX Meeting, Amsterdam, Netherlands
  • 1990 German Cancer Price
  • 1989 Prize of the Rheinisch-Westfälische Academy of Sciences, Germany
  • 1986 The Biochemical Society 75th Anniversary Symposium Honoured Lecture, London, UK
  • 1985 GUM Prize
  • 1983 Walter Straub Memorial Lecture, Munich, Germany
  • 1982 Robert Koch Prize
  • 1977 Professor Max Cloetta Prize

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