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Prof. Dr.

Kathleen J. Green

Year of election: 2016
Section: Internal Medicine and Dermatology
City: Chicago
Country: USA
CV Kathleen J. Green - Deutsch (PDF)
CV Kathleen J. Green - English (PDF)

Research

Main research interests: Pathology, dermatology, cell adherence mechanisms, cell biology, cytoskeleton

Katheen J. Green investigates the function and regulation of adherent junctions that mediate cell–cell adhesion and attachment of the cytoskeleton to the cell surface. In particular she focuses on intercellular junction molecules that make up plasma membrane organelles called desmosomes. Defects in desmosome components caused by mutation or post-translational modification cause a number of pathologies ranging from skin and cardiac disease to cancer.

Communication between cells in multicellular organisms is vital for human existence. Kathleen J. Green’s research is dedicated to advancing the understanding of the molecular foundations of cellular communication and to analyzing how cells adhere to each other. The purpose of adhesion is not only to ensure the mechanical strength of tissue but also to regulate the key chemical signals required for development and differentiation. Green is particularly interested in cell and heart tissues that are especially susceptible to adhesions. This includes hereditary diseases and illnesses conveyed by bacterial toxins or caused by cancer.

Career

  • since 2015 Associate Director, Basic Sciences, R.H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, USA
  • since 2011 Associate Director, Skin Disease Research Center Keratinocyte Core, Northwestern University Medical School, Chicago, USA
  • 2009-2011 Director, Skin Disease Research Center Keratinocyte Core, Northwestern University Medical School, Chicago, USA
  • since 1997 Professor, Dept. of Pathology and Dermatology, Northwestern University Medical School, Chicago, USA
  • since 1996 Associate Chair, Research and Graduate Education, Dept. of Pathology, Northwestern University Medical School, Chicago, USA
  • 1993-1997 Associate Professor, Dept. of Pathology and Dermatology, Northwestern University Medical School, Chicago, USA
  • 1987-1993 Assistant Professor, Dept. of Pathology and Cancer Center, Northwestern University Medical School, Chicago, USA
  • 1987 Research Assistant Professor, Dept. of Cell Biology and Anatomy, Northwestern University Medical School, Chicago, USA
  • 1984-1985 Associate Instructor, Marine Biological Laboratory, University of Chicago, USA
  • 1982-1987 Postdoc, Northwestern University Medical School, Chicago, USA
  • 1982-1983 Teaching Assistant, Marine Biological Laboratory, University of Chicago, USA
  • 1982 PhD, Washington University in St. Louis, USA
  • 1978-1980 Teaching Assistant, Washington University in St. Louis, USA
  • 1976-1977 Teaching Assistant, Pomona College, Claremont, USA
  • until 1977 Studies in Biology, Pomona College, Claremont, USA

Projects

  • 2015-2016 Co-Investigator, “Inter-junctional signaling in epithelial junctional complex”
  • 2009-2015 Core Member, “Structural Alterations in the Myocardium and the Substrate for Cardiac Fibrillation”
  • since 2006 PrincipaI Investigator, “Regulation of Desmosomal Cadherins in Oral Cancer”
  • 2006-2015 Program Leader, “TIMA (Tumor Invasion, Metastasis and Angiogenesis)”, R.H. Lurie Cancer Center, Northwestern University, Evanston, USA
  • since 1998 PrincipaI Investigator, “Carcinogenesis Training Program”
  • since 1996 PrincipaI Investigator, “Desmoplakin Assembly and Function in Epidermis”
  • since 1993 PrincipaI Investigator, “Function of Desmoglein 1/ Pemphigus Foliaceus Antigen”

Honours and Memberships

  • since 2016 Member, German National Academy of Sciences Leopoldina
  • 2015 Humboldt Research Award, Alexander von Humboldt Foundation
  • 2015 Kligman Frost Leadership Award, Society for Investigative Dermatology
  • 2012 Martin and Gertrude Walder Award for Research Excellence
  • 2011 Method to Extend Research in Time Award, National Institutes of Health
  • 2011 Women in Science and Society Lectureship, Universität zu Köln
  • 2011 Distinguished Women in Medicine and Science Award Lecture, Northwestern University, Evanston, USA
  • 2006 Tanioku Kihei Memorial Award Lecture, Japanese Society for Investigative Dermatology
  • 2001-2004 Keith Porter Fellow
  • 2002 William Montagna Award Lecture, Society for Investigative Dermatology
  • since 1999 Joseph L. Mayberry Professorship
  • 1999 Fellow, American Association for the Advancement of Science (AAAS)
  • 1993-1998 American Cancer Society Faculty Research Award
  • 1992-1995 Johnson & Johnson Focused Giving Award
  • 1990-1993 American Cancer Society Junior Faculty Research Award
  • 1988-1991 March of Dimes Basil O'Connor Starter Scholar
  • 1981 MBL Physiology Course Award
  • 1980 ASCB Young Scientist Award
  • 1973 Pomona College Scholar

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