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Prof. Dr.

Marina V. Rodnina

Year of election: 2008
Section: Biochemistry and Biophysics
City: Göttingen
Country: Germany
CV Marina V. Rodnina - Deutsch (pdf)

Research

Marina Rodnina has developed novel approaches to study the function of the ribosome as a macromolecular machine. She pioneered the use of kinetic and fluorescence methods in conjunction with quantitative biochemistry to solve the mechanisms of translation. The major scientific accomplishments include the discovery of the induced-fit mechanism of tRNA selection by the ribosome. This entirely new concept provided the basis for the interpretation of the interactions and conformational changes in the crystal structure of ribosomes and cryo-EM reconstructions of ribosome complexes.

Marina Rodnina has identified the translational GTPase EF-G as motor protein, rather than a regulatory switch, and contributed to understanding the functional parallels between GTPases and motor proteins. Recently, her group solved the long-standing question of the chemical mechanism of peptide bond formation on the ribosome. As the ribosome is an ancient RNA-based enzyme, these findings shed the light on the evolution of enzyme catalysis.

Marina Rodnina was able to establish herself as one of the world’s authorities in several important areas of biochemistry and biophysics: the ribosome function, particularly using rapid kinetics and quantitative methods; the mechanism of translational GTPases; role of RNA dynamics in molecular recognition; and mechanism of antibiotic function.

Werdegang

  • seit 2008 Direktorin und Leiterin der Abteilung physikalische Biochemie, Max‐Planck‐Institut für Biophysikalische Chemie, Göttingen
  • 2000-2008 Inhaberin des Lehrstuhls für Physikalische Biochemie, Private Universität Witten/Herdecke
  • 1998-2000 Professorin an der Privaten Universität Witten/Herdecke, Institut für Molekularbiologie
  • 1997 Habilitation in Biochemie, Private Universität Witten/Herdecke
  • 1992-1997 Wissenschaftliche Assistentin, Private Universität Witten/Herdecke
  • 1990-1992 Forschungsstipendiatin der Alexander von Humboldt‐Stiftung, Private Universität Witten/Herdecke
  • 1989 Promotion in Molekularbiologie und Genetik, National Taras Shevchenko University Kiew, Ukraine
    1982-1990 Wissenschaftliche Mitarbeiterin, National Taras Shevchenko University Kiew, Ukraine
  • 1977-1982 Studium der Biologie, Schwerpunkt Molekularbiologie und Genetik, an der National
    Taras Shevchenko University Kiew, Ukraine

Funktionen

  • 2011-2015 Stellvertretende Sektionssprecherin, Sektion Biochemie, Biophysik, Strukturbiologie und Bioinformatik, Deutsche Forschungsgemeinschaft (DFG)
  • 2010-2013 Fachgutachterin European Research Council (ERC)
  • 2008-2012 Gewählte Fachgutachterin der Deutschen Forschungsgemeinschaft (DFG)
  • 2007-2009 Board of Directors, The RNA Society
  • Mitarbeit in fünf Editorial Boards, regelmäßig Gutachterin für eine Vielzahl wissenschaftlicher Journale

Projekte

  • seit 2010 DFG SFB 860 „Integrative Strukturbiologie dynamischer makromolekularer Komplexe“, Teilprojekt „Zeitliche und strukturelle Dynamik der tRNA‐Bewegung am Ribosom“

Auszeichnungen und Mitgliedschaften

  • 2016 Gottfried Wilhelm Leibniz-Preis der Deutschen Forschungsgemeinschaft (DFG)
  • seit 2008 Mitglied der Nationalen Akademie der Wissenschaften Leopoldina
  • seit 2004 Mitglied der European Molecular Biology Organization (EMBO)

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