Leopoldina Menü

Leopoldina Home

Members

List of Members | Expert Search

Search among the members of the Leopoldina for experts in specific fields or research topics. After entering a name in the "Name" field, click on "Search" to go directly to a member profile. With the input and selection in the fields "City" and „Country", you can limit your search locally or regionally, or target specific sections of the Leopoldina. Alternatively or in combination a full-text search is possible for all member profiles - use the upper input field. The use of operators like AND, NOT or * is permitted in the full-text search. For example, you may search for "genetics" or "*genet*" to get results with "genetic" or "molecular genetics". For a new search please click on the following link or use the full-text search in the right column.

New Search

Prof. Dr.

Michael Reth

Year of election: 2006
Section: Microbiology and Immunology
City: Freiburg (Br.)
Country: Germany
CV Michael Reth - Deutsch (pdf)
CV Michael Reth - Englisch (PDF)

Research

My group works on differentiation and activation mechanisms of B lymphocytes of the mammalian immune system. Our work resulted in a better description of the B cell antigen receptor and we discovered several critical signal elements in B lymphocytes. Since 1998 we are applying synthetic biology approaches for a better study of signaling processes in lymphocytes. With this approach we made several key discoveries that resulted in a new hypothesis for B cell activation, namely the dissociation-activation model (DAM). In our signaling studies we are currently combining biochemical, genetic, molecular biology and synthetic biology techniques. We also have developed a modification of the proximity ligation assay (PLA) which allows us to study the molecular interactions around receptors of lymphocytes at the 10-20 nanometer range. With this technique we discover a new world of nanoscale molecular interaction in and at the membrane and open a venue to the field of Nanobiology.

Career

  • since 2007 Scientific director of BIOSS Centre for Biological Signalling Studies, funded by the excellence programme of the German government
  • since 1996 Professor of Molecular Immunology, University of Freiburg, Germany
  • 1996-1998 Associate Professor (C3), MPI for Immunobiology, Freiburg, Germany
  • 1988 Habilitation, University of Cologne, Germany
  • 1985-1988 Group Leader, Institute of Genetics, University of Cologne, Germany
  • 1982-1985 Visiting Research Fellow, Columbia University, New York, USA
  • 1981 Ph.D. University of Cologne, Germany
  • 1971-1977 Diploma, University of Cologne, Germany

Projects

(Selection)

  • 2014-2017 TRR130 The resting state of B lymphocytes
  • 2007-2014 CRC746, Modifications and adaptor function of the B cell signalling proteins Syk and SHP-1 (P7)
  • 2007-2012 BMBF, Freiburg Initiative for Systems Biology (FRISYS)
  • 2007-2017 BIOSS EXC294, Center for Biological Signalling Studies (BIOSS): from analysis to synthesis
  • 2002-2013 CRC620, Production and analysis of B-cell mutant mice with the Cre/loxP method (B5)

Functions

(Selection)

  • 2008 Honorary Member of the American Association of Immunologists
  • since 2005 Member of the Advisory Board of the of the IDI Institute, Harvard University, USA
  • since 2003 Editorial Board, Annual Review of Immunology
  • 1992-2007 Editorial Board, European Journal of Immunology
  • since 1990 Transmitting Editor, International Immunology

Honours and Memberships

(Selection)

  • 2014 Paul Ehrlich Prize
  • 2012-2017 ERC Advanced Grant
  • 2009 Schering-Plough Prize
  • 1995 Gottfried-Wilhelm-Leibniz Prize of the German Research Foundation (DFG)
  • 1995 Elected as EMBO-member
  • 1988 Heinz Maier Leibnitz Prize for Immunogenetics
  • 1982 German Research Foundation Postdoctoral Fellowship

CONTACT

Leopoldina

Archive


Emil-Abderhalden-Str. 35
06108 Halle (Saale)

Phone 0345 - 47 239 - 122
Fax 0345 - 47 239 - 139
E-Mail archiv @leopoldina.org

Expert Search

Academia Net

Profiles of Leading Women Scientists on AcademiaNet – an initiative of the Robert Bosch Stiftung.