Politics and society need realistic proposals on how to make the best use of future opportuni-ties in research and teaching in Germany. In its report on tomorrow’s science, the Leopoldina takes a position on systemic potentials and problems of scientific development in Germany which are considered to be particularly relevant for the relationship between science, politics and society in both the medium and long terms. The Leopoldina’s first report on tomorrow’s science focuses on rapid technological developments in the biosciences, as well as on the organizational challenges for both research and teaching arising from these breakthroughs.