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UID:756-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:1st Symposium on Nucleic Acid Modifications
DESCRIPTION:The sequence genetic code based on the four canonical Watson-Cr
 ick nucleosides has been an accepted paradigm for decades, however, an impo
 rtant aspect of it has recently been overturned. We learned that additional
  nucleosides exist in DNA, which establish a second layer of information th
 at is important e.g. to differentiation processes. Along the same line, we 
 now start to understand that the numerous known modified RNA nucleosides ar
 e part of a similar “hidden” program that we are just beginning to understa
 nd.Indeed, deciphering the modified “genetic” code that is embodied by thes
 e modified DNA and RNA bases is currently one of the hottest topics in (Che
 mical) Biology. Unveiling the new hidden layer of information in the geneti
 c code beyond the classical four-letter alphabet is the aim of current rese
 arch effort, and of this conference. An analogues situation has emerged in 
 the RNA field. Regulatory mechanisms acting on the transcriptome are centra
 l to cellular processes governing cell biology, development and tissue func
 tion. RNA modifications are merging key players in the field of posttranscr
 iptional regulation of gene expression, and are now attracting a level of r
 esearch interest equal to DNA and histone modifications in the field of epi
 genetics. The true potential of only a handful out of more than 100 RNA mod
 ifications is currently emerging as the consequence of a leap in technology
 , most of which is associated to high throughput sequencing, and thus appli
 cable to epitranscriptome wide studies. Picture: Leigh Prather\n\nContact\n
 \nProf. Dr. Mark HelmInstitute of Pharmacy and Biochemistry - Therapeutical
  Life SciencesJohannes Gutenberg-Universität MainzE-Mail: mhelm@uni-mainz.d
 eTel.: 06131 39-25731
LOCATION:Mainz
DTSTAMP:20251112T170935Z
DTSTART:20170904T070000Z
DTEND:20170906T160000Z
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