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UID:997-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:Bacterial Methylomes
DESCRIPTION:Nobel laureate Sir Richard J. Roberts (UK/USA) focuses in his p
 resentation on bacterial DNA methyltransferases (MTases), which are best kn
 own as orphan enzymes such as the Dam methylase of E. coli or as components
  of restriction-modification (RM) systems. Until recently, rigorously deter
 mining the specificity of MTases has been a tedious process. When they were
  components of Type II restriction systems it has been assumed that the MTa
 ses would have the same specificity as the cognate restriction enzyme. For 
 Type I and Type III RM systems specificity determination was rarely attempt
 ed. With the advent of SMRT sequencing from Pacific Biosciences this situat
 ion has changed dramatically. Now it has become very simple to determine MT
 ase recognition sequences both for individual MTases cloned in plasmids and
  also for whole bacterial genomes. This offers new insights into the functi
 oning of bacteria and has led to the discovery of many novel MTases with un
 expected properties. A new door on bacterial life has been opened and raise
 s many questions.  \n\nSir Richard J. Roberts\n\n  is the Chief Scientific 
 Officer at New England Biolabs, Beverly, Massachusetts.  He was awarded the
  1993 Nobel Prize in Physiology or Medicine with Phillip Allen Sharp for th
 e discovery of introns in eukaryotic DNA and the mechanism of gene-splicing
 .\n\nFurther information and Registration\n\nThe presentation will be held 
 in English. Participation is free of charge. Please register until 23 May 2
 014. Registration\n\nContact\n\nDr Jan NissenGerman National Academy of Sci
 ences LeopoldinaTel. +49 (0)345 - 47239 - 834jan.nissen@leopoldina.org
LOCATION:Halle (Saale)
DTSTAMP:20251112T170935Z
DTSTART:20140526T163000Z
DTEND:19700101T190000Z
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