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UID:213-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:Developing mRNA for therapy
DESCRIPTION:Messenger RNA was discovered in 1961. But it took 60 years for 
 the first mRNA to be approved by the FDA in the form of the COVID-19 mRNA v
 accine. During that time a lot of progress has been made by hundreds of sci
 entists. In 1978, for example, when the first-time isolated mRNA delivered 
 into mammalian cells produced the encoded protein. In vitro transcription i
 ntroduced in 1984, made it possible to generate mRNA from the encoding plas
 mid using phage RNA polymerases. In the 1990s mRNA was used for therapy as 
 well as vaccine in animal studies. However, the nucleoside uridine made mRN
 A inflammatory and too little amount of protein was produced from mRNA. By 
 replacing uridine with the modified version pseudouridine, the mRNA became 
 non-inflammatory, more stable and highly translatable. mRNA is revolutioniz
 ing the delivery of effective and safe vaccines, and therapeutics.\n\nKatal
 in Karikó ML is a Hungarian biochemist. After studying biology and obtainin
 g her PhD at the University of Szeged, she worked at the Biological Researc
 h Center of the Hungarian Academy of Sciences and later at the University o
 f Pennsylvania in the USA, among others. Throughout her research career, sh
 e focused on RNA-mediated mechanisms. Her work enabled the development of m
 RNA-based vaccines against SARS-Cov-2 in 2020, only a few months after the 
 virus appeared. Karikó has been honored for her contributions with countles
 s awards, honorary doctorates and memberships. She was Senior Vice Presiden
 t at BioNTech between 2013 and 2022.\n\nML = Member of the Leopoldina\n\nFu
 rther Information\n\nThe event is aimed at all interested parties and will 
 be held in English. Registration is required.To the registration\n\nContact
 \n\nDr. Henning SteinickeDepartment Science - Policy - SocietyTel.: +49 (0)
 345 47 239 - 864Mail: politikberatung@leopoldina.org
LOCATION:Lecture Hall of the Leopoldina
DTSTAMP:20251125T084557Z
DTSTART:20230419T150000Z
DTEND:20230419T174500Z
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