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UID:782-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:Grid Cells and the Brain’s Map of Space
DESCRIPTION:The medial entorhinal cortex (MEC) is part of the brain’s circu
 it for dynamic representation of self-location. A key component of this rep
 resentation is the grid cell, whose spatial firing fields tile environments
  in a periodic hexagonal pattern, like in a Chinese checkerboard. The MEC c
 ircuit contains also other functional cell types, such as head direction ce
 lls and border cells, which are intermingled among the grid cells. In this 
 lecture Nobel laureate and Leopoldina member, Edvard Moser, will review evi
 dence pointing to MEC network properties as elements of the mechanism for g
 rid formation. Moser will further demonstrate that running speed is represe
 nted in the firing rate of a ubiquitous but functionally dedicated populati
 on of MEC neurons, and I will show that speed is represented across a wider
  brain circuit that includes speed cells in the mesencephalic locomotor reg
 ion, whose outputs may reach the MEC via speed cells in the diagonal band o
 f Broca.  Finally I will present data pointing to some of the mechanisms un
 derlying the early development of the grid-cell system. I will show that ma
 turation of the entorhinal-hippocampal circuit is driven by excitatory acti
 vity in the stellate cells of the MEC, with stellate cells instructing prog
 ressive maturation through the entorhinal-hippocampal circuit. With the dis
 covery of place cells and grid cells, as well as other co-localized spatial
  cell types, it has become possible to study neural computation at the high
  end of the cortical hierarchy, quite independently of sensory inputs and m
 otor outputs. The presence of an experimentally controllable spatial firing
  correlate, combined with the access to activity patterns of multiple discr
 ete cell types, provides researchers with a model system to determine not o
 nly how specific activity patterns are generated but also how activity gets
  transformed from one cell type to another. Picture: Ned Alley\n\nFurther I
 nformation and Registration\n\nThe lecture is open to anyone interested and
  free of charge. Please register under the following link. Registration\n\n
 Contact\n\nDr. Katja PatzwaldtScientific Officer, Presidential OfficeTel.: 
 030 / 203 8997 431E-Mail: katja.patzwaldt@leopoldina.org
LOCATION:Berlin
DTSTAMP:20251112T170935Z
DTSTART:20170515T150000Z
DTEND:20170515T180000Z
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