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UID:701-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:[Entfällt] Next Generation Environmentally Friendly Antibiotics
DESCRIPTION:Resistance to antibiotics is a severe problem in contemporary m
 edicine. Many antibiotics inhibit protein biosynthesis by hampering the rib
 osome function. Structures of bacterial ribosomes in complex with these ant
 ibiotics illuminated common pathways of antibiotics inhibitory action, but 
 not the species-specific diversity in infectious-diseases susceptibility.\n
 \nRecent structural studies on ribosome from a multi-resistant pathogenic b
 acterium and careful comparisons to ribosomes from non-pathogenic bacteria 
 revealed novel structural motifs, essential to protein biosynthesis but not
  located in the primary ribosomal active sites, hence no mechanism for modi
 fication leading to resistance of these sites is currently known. These led
  to the design of antibiotics with desired properties that can be optimized
  in terms of their chemical properties, toxicity and penetration, alongside
  species-specificity, thus preserving the microbiome, as well as in terms o
 f bio degradability, thus reducing the ecological hazards caused by the spr
 ead of the current antibiotics’ metabolites.\n\nProf. Dr. Ada Yonath\n\nNob
 el laureate Ada Yonath is Martin S. and Helen Kimmel Professor of Structura
 l Biology and Director of the Helen and Milton A. Kimmelman Center for Biom
 olecular Structure and Assembly at the Weizmann Institute of Science in Rec
 hovot, Israel. She has been awarded numerous prizes and honorary doctorates
  and is member of many national academies of science, including the German 
 National Academy of Sciences Leopoldina. In the year 2009, Yonath won the N
 obel Prize for Chemistry, sharing it with Venkatraman Ramakrishnan and Thom
 as A. Steitz. The Nobel committee honoured their “studies of the structure 
 and function of the ribosome”. Ada Yonath pioneered the use of X-ray crysta
 llography in her field in Israel, and after decades of work she discovered 
 the atomic structure of the ribosome, as well as the action of several anti
 biotics targeting the ribosome.\n\nLinks\n\nMitgliedsprofil von Ada Yonath 
 \n\nWichtiger Hinweis\n\nDie Veranstaltung entfällt. 
LOCATION:Berlin
DTSTAMP:20251112T170935Z
DTSTART:20180508T160000Z
DTEND:20180508T180000Z
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