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UID:783-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:Grid Cells and the Brain’s Map of Space
DESCRIPTION:The medial entorhinal cortex (MEC) is part of the brain’s circu
 it for dynamic representation of self-location. A key component of this rep
 resentation is the grid cell, whose spatial firing fields tile environments
  in a periodic hexagonal pattern, like in a Chinese checkerboard. The MEC c
 ircuit contains also other functional cell types, such as head direction ce
 lls and border cells, which are intermingled among the grid cells. In this 
 lecture Nobel laureate and Leopoldina member, Edvard Moser, will review evi
 dence pointing to MEC network properties as elements of the mechanism for g
 rid formation. Moser will further demonstrate that running speed is represe
 nted in the firing rate of a ubiquitous but functionally dedicated populati
 on of MEC neurons, and he will show that speed is represented across a wide
 r brain circuit that includes speed cells in the mesencephalic locomotor re
 gion, whose outputs may reach the MEC via speed cells in the diagonal band 
 of Broca.  Finally he will present data pointing to some of the mechanisms 
 underlying the early development of the grid-cell system. He will show that
  maturation of the entorhinal-hippocampal circuit is driven by excitatory a
 ctivity in the stellate cells of the MEC, with stellate cells instructing p
 rogressive maturation through the entorhinal-hippocampal circuit. With the 
 discovery of place cells and grid cells, as well as other co-localized spat
 ial cell types, it has become possible to study neural computation at the h
 igh end of the cortical hierarchy, quite independently of sensory inputs an
 d motor outputs. The presence of an experimentally controllable spatial fir
 ing correlate, combined with the access to activity patterns of multiple di
 screte cell types, provides researchers with a model system to determine no
 t only how specific activity patterns are generated but also how activity g
 ets transformed from one cell type to another. Foto: Ned Alley\n\nFurther I
 nformation and Registration\n\nThe lecture is open to anyone interested and
  free of charge. Please register under the following link. Registration\n\n
 Contact\n\nDr. Katja PatzwaldtScientific Officer, Presidential OfficeTel.: 
 030 / 203 8997 431E-Mail: katja.patzwaldt@leopoldina.org
LOCATION:Berlin
DTSTAMP:20251112T170935Z
DTSTART:20170515T150000Z
DTEND:20170515T180000Z
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