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UID:1652-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:How viruses enter their host cells.
DESCRIPTION:Viruses replicate within living cells and make use of the cellu
 lar machinery for synthesis of their genome and other components. To gain a
 ccess, they have evolved a variety of elegant mechanisms to deliver their g
 enes and accessory proteins into the host cell. We find that most animal vi
 ruses take advantage of endocytic pathways, and rely on the cell to guide t
 hem through a complex entry and uncoating program. In the dialogue between 
 the cell and the intruder, the cell provides critical cues that allow the v
 irus to undergo molecular transformations that lead to successful internali
 zation, intracellular transport, and uncoating. The virus in turn makes use
  of the cells signaling pathways to send messages into the cell that make e
 ntry possible. [Viren vermehren sich in lebenden Zellen und bedienen sich d
 abei der Maschinerie der befallenen Zelle. Im Vortrag werden Mechanismen be
 schrieben, die Viren entwickelt haben, um in die Zelle eindringen und sie z
 u ihren Gunsten umzuprogrammieren.]Ari Helenius: Candidate of Philosophy (B
 iochemistry) Univ. Helsinki (1970); Doctor of Philosophy, Univ. Helsinki (1
 973); Junior Investigator at the Finnish Academy of Natural Sciences (1974-
 1975); Staff Scientist at the European Molecular Biology Laboratory, Heidel
 berg (1975- 1981); Associate Professor of Cell Biology, Yale University Sch
 ool of Medicine (1981-1983); Professor of Cell Biology, Yale University Sch
 ool of Medicine (1983-1997); Professor of Molecular, Cellular and Developme
 ntal Biology, Yale University (1987-present); Chairman of Cell Biology Depa
 rtment, Yale University School of Medicine (1992-1997); Professor of Bioche
 mistry, Swiss Federal Institute of Technology (ETHZ) (1997- present); Chair
 man (Vorsteher) ETHZ Institute of Biochemistry (1999-2003). Numerous editor
 ships, outstanding prizes and awards. Among them: Alexander von Humboldt Re
 search Award (1991-1992), Lamb Professor of Molecular Pathogenesis, Vanderb
 ilt University (1992), NICHD Lectureship in Cell Biology (1992), Honorary P
 rofessor Davila Univ. Bucharest, Romania (1993), A.I. Virtanen Prize in Bio
 chemistry (1995). The Spinoza Guest Professorship, Univ. Amsterdam (1997), 
 Member of the European Molecular Biology Organization (EMBO, since 1999); M
 ember of Leopoldina, Sektion Biochemie und Biophysik (since 2001), Ernst-Ju
 ng Preis für Medizin 2003, Schleiden-Medaille der Leopoldina (2003).Forschu
 ngsschwerpunkte: Arbeiten zu grundlegenden und krankheitsrelevanten Aspekte
 n 1) der Proteinfaltung und Proteinreifung und 2) der Virus-Zell Interaktio
 nen.Kontaktadresse: Prof. Dr. Ari Helenius, ETH Hönggerberg, HPM E 6.3 Inst
 itut für Biochemie, Schaffmattstrasse 18, CH-8093 Zürich
LOCATION:Halle
DTSTAMP:20251112T170935Z
DTSTART:20041122T230000Z
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