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PRODID:https://github.com/derhansen/sf_event_mgt
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UID:1244-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:International Workshop "Physicochemical fundamentals of DNA hybridi
 zations on surfaces  as applied to microarrays and bead-based sequencing te
 chnologies"
DESCRIPTION:Many fields of biological science depend upon accurate identifi
 cation and quantification of nucleic acid targets because these targets ind
 irectly reflect the state of a biological system. Oligonucleotide microarra
 ys were once thought to be the big hope for the high-throughput identificat
 ion and quantification of nucleic acids. At that time, it was believed that
  designing probes for microarrays and interpreting results was mostly a bio
 informatics/statistical exercise. However, it turned out, that interpreting
  the signal from microarrays was a major challenge in terms of surface chem
 istry because many details, such as the interactions between nucleic acid t
 argets in solution and oligonucleotide probes on a microarray surface, were
  not well understood.We consider microarray technology as an instrument for
  measuring concentrations in multicomponent mixtures of DNA or RNA species.
  From this point of view, selectivity, response function and reproducibilit
 y must be known for appropriate analytics in real world applications. Other
  laboratories devised ad hoc approaches to make biological sense of microar
 ray signals.  These approaches have been extensively implemented and are no
 w widely accepted in the published literature. Recent significant advanceme
 nts in the understanding of nucleic acid hybridization and dissociation on 
 microarray surfaces have revealed a number of inconsistencies between physi
 cal chemistry and the ad hoc approaches.The purpose of this workshop is thr
 ee-fold: (i) to update developments in the understanding and application of
  microarrays, (ii) to identify and resolve inconsistencies in microarray an
 alytics, and (iii) to discuss the future of microarray technology from the 
 perspective of measuring principles and potential applications.  We believe
  that this workshop is essential for moving forward microarray research and
  also for the advancement of new technologies such as ‘next-generation’ seq
 uencing, which depend upon surface-hybridizations and array capture.Website
LOCATION:Max-Planck-Institut für Evolutionsbiologie, August-Thienemann-Stra
 ße 2, 24306 Plön
DTSTAMP:20251112T170935Z
DTSTART:20110508T220000Z
DTEND:20110511T220000Z
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