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UID:624-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:Next Generation Environmentally Friendly Antibiotics
DESCRIPTION:Resistance to antibiotics is a severe problem in contemporary m
 edicine. Many antibiotics inhibit protein biosynthesis by hampering the rib
 osome function. Structures of bacterial ribosomes in complex with these ant
 ibiotics illuminated common pathways of antibiotics inhibitory action, but 
 not the species-specific diversity in infectious-diseases susceptibility.Re
 cent structural studies on ribosome from a multi-resistant pathogenic bacte
 rium and careful comparisons to ribosomes from non-pathogenic bacteria reve
 aled novel structural motifs, essential to protein biosynthesis but not loc
 ated in the primary ribosomal active sites, hence no mechanism for modifica
 tion leading to resistance of these sites is currently known. These led to 
 the design of antibiotics with desired properties that can be optimized in 
 terms of their chemical properties, toxicity and penetration, alongside spe
 cies-specificity, thus preserving the microbiome, as well as in terms of bi
 o degradability, thus reducing the ecological hazards caused by the spread 
 of the current antibiotics’ metabolites. \n\nWeitere Informationen und Anme
 ldung\n\nDie Veranstaltung richtet sich an alle Interessierten. Der Eintrit
 t ist frei. Eine Anmeldung ist erforderlich.\n\nAnmeldung \n\nKontakt\n\nDr
 . Katja PatzwaldtWissenschaftliche ReferentinTel.: 030 - 203 8997 - 431E-Ma
 il: katja.patzwaldt@leopoldina.org
LOCATION:Berlin
DTSTAMP:20251112T170935Z
DTSTART:20190612T160000Z
DTEND:20190612T180000Z
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