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PRODID:https://github.com/derhansen/sf_event_mgt
METHOD:PUBLISH
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UID:909-96@www.leopoldina.org
CLASS: PUBLIC
SUMMARY:Optical and chemical tools for high-resolution investigation of int
 act biological systems
DESCRIPTION:The lecture will address optical tools for precise, high-resolu
 tion investigation of intact biological systems, and application of these t
 ools to study the neural circuit underpinnings of adaptive and maladaptive 
 behavior. Over the last years we have developed both optogenetics and CLARI
 TY, a technology to optically resolve high-resolution structural and molecu
 lar detail within intact tissues without disassembly. Most recently in opto
 genetics, our team has developed strategies for targeting microbial opsins 
 and light to meet the challenging constraints of the freely-behaving mammal
 , engineered a panel of microbial opsin genes spanning a range of optical a
 nd kinetic properties, built high-speed behavioral and neural activity-read
 out tools compatible with real-time optogenetic control, and applied these 
 optogenetic tools to develop circuit-based insight into anxiety, depression
 , and motivated behaviors. With CLARITY, whole mouse brains have now been l
 abeled and imaged, and molecular markers have been used to identify individ
 ual structures and projections in banked human brain tissue, thereby unlock
 ing rich sources of information for probing disease mechanisms as well as t
 he native structure and complexity of the nervous system, in a manner compl
 ementary to optogenetic approaches.  \n\nProf. Dr. Karl Deisseroth\n\n  is 
 Professor of Bioengineering and of Psychiatry and Behavioral Sciences at St
 anford University, and Investigator of the Howard Hughes Medical Institute.
  He studied in Harvard and at Stanford, where he received his PhD. He conti
 nues as a practicing psychiatrist with specialization in affective disorder
 s and autism-spectrum disease. He is best known for developing optogenetics
  and CLARITY (see abstract). He has employed these technologies to discover
  the neural cell types and connections that cause adaptive and maladaptive 
 behaviors, and has disseminated the technologies to thousands of laboratori
 es around the world. For his discoveries, Deisseroth has received numerous 
 awards and prizes. He was elected to the US National Academy of Sciences in
  2012, and to the German National Academy of Sciences Leopoldina in 2014.Fo
 to: © Gunter Binsack\n\nFurther Information\n\nNo registration is required.
  The lecture is free of charge.
LOCATION:Halle (Saale)
DTSTAMP:20251112T170935Z
DTSTART:20150708T160000Z
DTEND:20150708T170000Z
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