Nova Acta Leopoldina Band 110 Nummer 377

Wie funktioniert das Leben? Nova Acta Leopoldina NF 110, Nr. 377, 11–44 (2011) 43 Dank Ich danke Francisco DOMINGUES für eine ausführliche Kommentierung des Entwurfs dieser Arbeit, hilfreiche Dis- kussionen zu zahlreichen der angesprochenen Themen sowie die Bereitstellungen der Abbildungen 4, 6, und 10. Ferner danke ich Hagen BLANKENBURG, Christoph BOCK, Alejandro PIRONTi, Ingolf SOMMER und Alexander THIELEN für eine kritische Durchsicht des Manuskripts. Literatur ATKINS, J. F., and GESTELAND, R.: Biochemistry. The 22nd amino acid. Science 296/5572, 1409–1410 (2002) BOCK, C., and LENGAUER, T.: Computational epigenetics. Bioinformatics 24/1, 1–10 (2008) BONNEAU, R.: De novo structure prediction: Methods and applications. In: LENGAUER, T. (Ed.): Bioinformatics – From Genomes to Therapies; pp. 389–418. Weinheim: Wiley-VCH 2007 BOzEK, K., THIELEN,A., SIERRA, S., KAISER, R., and LENGAUER, T.: V3 Loop sequence space analysis suggests different evolutionary patterns of CCR5- and CXCR4-tropic HIV. PLoS ONE 4/10, e7387 (2009) BRUTLAG, D. L.: Inferring protein function from sequence. In: LENGAUER, T. (Ed.): Bioinformatics – From Genomes to Therapies; pp. 1087–1121. Weinheim: Wiley-VCH 2007 DOMINGUES, F. S., and LENGAUER, T.: Inferring protein function from protein structure. In: LENGAUER, T. (Ed.): Bioin- formatics – From Genomes to Therapies; pp. 1211–1252. Weinheim: Wiley-VCH 2007 DUNBRACK, R. L. Jr.: Homology modeling in biology and medicine. In: LENGAUER, T. (Ed.): Bioinformatics – From Genomes to Therapies; pp. 297–350. Weinheim: Wiley-VCH 2007 FELSENFELD, G., and GROUDINE, M.: Controlling the double helix. Nature 421/6921, 448–453 (2003) GRANT, A., LEE, D., and ORENGO, C.: Progress towards mapping the universe of protein folds. Genome Biol. 5/5, 107 (2004) HANNENHALLI, S.: Eukaryotic transcription factor binding sites – modeling and integrative search methods. Bioinfor- matics 24/11, 1325–1331 (2008) HASSELDINE, A., LIPSHTAT, A., IyENGAR, R., and MáAyAN, A.: Modeling cell signaling networks. In: LENGAUER, T. (Ed.): Bioinformatics – From Genomes to Therapies; pp. 829–860. Weinheim: Wiley-VCH 2007 HE, y. D.: Genomic approach to biomarker identification and its recent applications. Cancer Biomark. 2/3–4, 103– 133 (2006) HILDEBRANDT, A., KOHLBACHER, O., and LENHOF, H.-P.: Modeling protein-protein and protein-DNA docking. In: LENGAUER, T. (Ed.): Bioinformatics – From Genomes to Therapies; pp. 601–650. Weinheim: Wiley-VCH 2007 HOCHHEISER, H., ELICEIRI, K. W., and GOLDBERG, I. G.: Visualization of biological data. In: LENGAUER, T. (Ed.): Bioin- formatics – From Genomes to Therapies; pp. 573–626. Weinheim: Wiley-VCH 2007 KLEPEIS, J. L., LINDORFF-LARSEN, K., DROR, R. O., and SHAW, D. E.: Long-timescale molecular dynamics simulations of protein structure and function. Curr. Opin. Struct. Biol. 19/2, 120–127 (2009) KOHL, P., and NOBLE, D.: Systems biology and the virtual physiological human. Mol. Syst. Biol. 5, 292 (2009) KOONIN, E. V.: Orthologs, paralogs, and evolutionary genomics. Annu. Rev. Genet. 39, 309–338 (2005) KOONIN, E. V., WOLF, y. I., and KAREV, G. P.: The structure of the protein universe and genome evolution. Nature 420/6912, 218–223 (2002) LEE, W. P., and TzOU, W. S.: Computational methods for discovering gene networks from expression data. Brief Bioinform. 10/4, 408–423 (2009) LENGAUER, T.: Future trends. In: LENGAUER, T. (Ed.): Bioinformatics – From Genomes to Therapies; pp. 1651–1686. Weinheim: Wiley-VCH 2007 LENGAUER, T., and SING, T.: Bioinformatics-assisted anti-HIV therapy. Nature Rev. Microbiol. 4/10, 790–797 (2006) LIU, L. A., and BADER, J. S.: Structure-based ab initio prediction of transcription factor-binding sites. Methods Mol. Biol. 541, 23–41 (2009) MAJOR, F., and THIBAULT, P.: RNA tertiary structure prediction. In: LENGAUER, T. (Ed.): Bioinformatics – From Genomes to Therapies; pp. 491–539. Weinheim: Wiley-VCH 2007 MEDALIA, O., WEBER, I., FRANGAKIS, A. S., NICASTRO, D., GERISCH, G., and BAUMEISTER, W.: Macromolecular archi- tecture in eukaryotic cells visualized by cryoelectron tomography. Science 298/5596, 1209–1213 (2002) MENDES, N. D., FREITAS, A. T., and SAGOT, M. F.: Current tools for the identification of miRNA genes and their targets. Nucleic Acids Res. 37/8, 2419–2433 (2009)