Leopoldina Menü

Leopoldina Home

Mitglieder

Mitgliederverzeichnis | Expertensuche

Prof. Dr.

Bruno Gottstein

Wahljahr: 2006
Sektion: Veterinärmedizin
Stadt: Bern
Land: Schweiz
CV Bruno Gottstein - Englisch (pdf)

Forschung

Schwerpunkt seiner Arbeiten ist die Erforschung experimenteller immun- und molekularbiologischer Prozesse bei der Wirts-Parasit-Interaktion bei der Infektion mit Echinococcus multilocularis. Erfolge wurden bei der Aufdeckung der Überlebensstrategie des Parasiten erzielt, indem T-Zell-unabhängige Karbohydratepitope identifiziert wurden, welche in der protektiven Laminarschicht des Metazestoden eine Schlüsselrolle bei der Immunevasion einnehmen. Dann konnte gezeigt werden, dass das tumorartige Wachstum des Metazestoden in der Leber seines Wirtes über die Hyperexpression eines 14-3-3-Proteins gesteuert wird. Dieses Protein erwies sich als geeigneter Vakzinekandidat zum Schutz vor einer primären peroralen Infektion.

Weitere Forschungsschwerpunkte befassen sich mit der Wirts-Parasit-Interaktion bei Infektionen mit Neospora caninum, Giardia lamblia, Tritrichomonas fetus, Trichinella spiralis sowie Naegleria fowleri.

Career

  • since 1992 Ordinarius in Veterinary and Medical Parasitology, University of Berne, Switzerland
  • 2004 CBA (Certificate in Business Administration), Universities of Fribourg and Trier, Germany
  • 2004 AssEVPC (European Veterinary Parasitology College)
  • 1991 Habilitation (Privatdozent) in Veterinary and Medical Parasitology, University of Zurich, Switzerland
  • 1989 Research Sabathical (to Dr. T.E. Nash), Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Md, USA
  • 1984-1985 Post-graduate Research Stay (to Dr. P.M. Schantz), Helminthic Diseases Branch, DPD, CID, Centers for Disease Control, Atlanta, USA
  • 1981-1992 Research and senior research assistant (to Prof. J. Eckert), Institute of Parasitology, University of Zurich, Switzerland
  • 1981 Ph.D., University of Bern, Switzerland
  • 1979 Diploma in Medical Microbiology
  • 1974-1979 Study of Medical Microbiology, University of Bern, Switzerland

Projects

  • 2009-2012 Research Grant, for “Echinococcus multilocularis and alveolar echinococcosis: the molecular struggle“, from the Swiss National Science Foundation, prolongation project No. 3100AO-111780
  • 2008-2010 Research Grant, for “Molecular and epidemiological invetigations on Naegleria fowleri and other neurotropic free-living amoebae”. FOCP-Project
  • 2007-2009 Research Grant, for “Toxoplasma gondii: Prevalences and Sources of infection in Switzerland“, from the Swiss Federal Veterinary Office
  • 2006-2009 Research Grant, for “Echinococcus multilocularis and alveolar echinococcosis: the molecular struggle“, from the Swiss National Science Foundation, project No. 3100AO-111780/1
  • 2006-2008 Research Grant, for “Development of a risk based surveillance program for Trichinella spp. in domestic swine and wildlife in Switzerland “, from the Swiss Federal Veterinary Office
  • 2005-2009 Research Grant, for “Assessment of  efficacy and efficiency of toltrazuril-treatment in newborn mice from Neospora-positive dams”, from Bayer Animal Health
  • 2004-2006 Research Grant, for “The parasite-host interplay in alveolar echinococcosis (larval infection with Echinococcus multilocularis)”; from the Swiss National Science Foundation, Project No. 31-63615.00 (2001-2004); bonus of excellence
  • 2003-2009 Research Grant, for “GCP study for the evaluation of serological tools to assess efficacy of toltrazuril-treatment in newborn calves from Neospora-positive dams”, from Bayer Animal Health
  • 2003-2005 Research Grant, for “Development and evaluation of diagnostic tools to identify infectious stages for the study of horizontal transmission risks in ruminant neosporosis, toxoplasmosis and sarcocystiosis (COST 854)”, from the BBW, Project No. 00.0498 [EU No. QLK2-CT-2001-01050]
  • 2003-2004 Research Grant, for “GCP study on the comparative evaluation of different time schedules for the metaphylactic treatment of Echinococcus multilocularis in dogs”, from Novartis Animal Health Inc.
  • 2003-2005 Research Grant, for “Epidemiologische Untersuchungen zur wirtschaftlichen Bedeutung von Neospora caninum beim Rind und zur epidemiologischen Bedeutung beim Hund in der Schweiz; Neo’03-05“, from the Swiss Federal Veterinary Office, Project no. 973.105/1.03.06
  • 2002-2003 Research Grant, for “Treatment and assessment of disease in human alveolar echinococcosis”. Novartis Foundation No. 01A04
  • 2002-2005 Research Grant, for “Protozoal reproduction losses in farm ruminants”. COST-854, from the BBW, project No. Project No. BBW C01.0122
  • 2001-2006 Research Grant, for “EchinoRisk: Risk assessment and prevention of alveolar echinococcosis”, from the BBW, Project No. 00.0586-1 [EU No. QLK-CT-2001-01995]
  • 2001-2005 Research Grant, for “Development of molecular tools to diagnose Naegleria fowleri and other neurotropic free-living amoebae”. GR-Project No. 4500303638
  • 2000-2003 Institutional Partnership Grant, for “ Public health impact of zoonoses”, (consortium grant with PD Dr. N. Müller and Prof. Dr. R. Kurdova), from the Swiss National Science Foundation, project No. 7 IP 62584

Functions

  • since 2010 Member of the Human Rights Committee of the Leopoldina National Academy of Sciences
  • since 2009 Board-member of the Executive Board of the Vetsuisse “Veterinary Public Health Institute”
  • 2009-2012 Board-member of the German Society for Parasitology
  • since 2000 Expert for the Swiss Accreditation Services (SAS) for the accreditation of Swiss medical and veterinary diagnostic laboratories (ISO 17025)
  • 1999-2006 President of the Swiss CASS-Commission for Polar Research
  • 1990-1993 President of the Swiss Society of Tropical Medicine and Parasitology (SSTMP)
  • since 1999 President of the Hans-Sigrist-Foundation for the promotion of Science at the University of Bern, Switzerland
  • since 2004 Associate Member of the European Veterinary Parasitology College
  • 1990-1994 Board-member (representative for Europe), World Association of Parasitology
  • since 1994 Delegate (representative for Switzerland, SSTMP), World Association of Parasitology
  • since 1994 Delegate (representative for Switzerland, SSTMP), European Federation of Parasitology

Honours and Memberships

  • 2012 Honorary Professor, University of Franche-Comté, France
  • 2006 Member of the German National Academy of Sciences Leopoldina
  • 2004 Honorary Member of the Bulgarian Society of Parasitology
  • 1993 Behring Bilharz Award
  • 1989 Promotion Prize of the Swiss Society of Microbiology, Switzerland

KONTAKT

Leopoldina

Archiv


Emil-Abderhalden-Str. 35
06108 Halle (Saale)

Tel. 0345 - 47 239 - 122
Fax 0345 - 47 239 - 139
E-Mail archiv @leopoldina.org

Expertensuche

Academia Net

Profile exzellenter Wissenschaftlerinnen bei AcademiaNet – eine Initiative der Robert Bosch Stiftung.