Professor Dr Christian Drosten

Research interests: Virology, coronaviruses, new emerging infectious diseases, diagnostic tests for viral infections
Christian Drosten is a physician and virologist. He works in the fields of viral diversity, ecology and epidemiology across the different evolutionary levels, from the natural reservoir of a pathogen right through to a global outbreak in the human population.
Virus discovery is a vital tool in understanding etiologically unclear disease presentations. Likewise, the characterisation of biological diversity is fundamental to understanding their evolutionary biology. However, the question of how we analyse the equidistance of unknown viruses remains unsolved. In recent years, Christian Drosten and his team have developed a strategy to describe significant new viruses, based on advanced cell culture systems and multi-pronged molecular characterisation. In addition, they have developed new bioinformatic approaches to identify viral sequences in meta-transcriptomic data.
Alongside this work, Christian Drosten has also been focusing on the expanding field of viral ecology, in particular the need to improve our understanding of viral diversity so that future pandemics can be identified early and prevented. What is still needed are concepts that make it possible to apply the complex relationships observed in viral ecology as part of a practical prevention strategy. Christian Drosten's research focuses on the dilution effect and speciation processes. He and his working group are looking at the concept of the species barrier, which they believe has functional correlates in terms of the interferon system and other cellular interactions. Their viral working models for this research are the coronaviruses, for which they have the relevant molecular biological repertoire.
During the discovery of the MERS (Middle East Respiratory Syndrome) coronavirus, Christian Drosten and his research group delivered some fundamental findings with regards to the epidemiology of the virus and disease progression. The current picture is that of a classic zoonosis with limited transmissibility, which can cause fulminant disease progression in individual cases, but appears relatively infrequently in the overall population. Christian Drosten and his team explored the evolution of the diversity and virulence of the MERS pathogen in the animal reservoir (dromedary camels). In comparison, the COVID-19 pandemic was caused by a highly transmissible coronavirus. Christian Drosten and his research group were again involved in studying the new virus and contributed to both diagnostics and clinical and virological characterisation of the disease.