Professor Dr Peter G. Wolynes

Research Priorities: Biophysics, energy dynamics, protein folding, cell biology, glass theory
Peter G. Wolynes is an US-American chemist, who applies physical methods onto biological problems. He concerned himself with a variety of theoretical questions at the interface of physics, chemistry, and biology, including the glass-transition of molecular fluids. A main focus of his research is in protein folding. Peter Wolynes developed methods to simulate the folding of proteins and to more accurately predict them.
Proteins are made up of amino acids, whose sequence determines their form. The protein will only adopt their three-dimensional structure during folding. Folding generally happens spontaneously once a protein is synthesized. However, there are certain proteins, called chaperons that aid in folding and that make sure the protein adopts the correct structure. If a protein is folded incorrectly, it cannot fulfil its proper function and may do great harm. Deficiently folded proteins play a part in Alzheimer’s disease, Parkinson’s disease or Huntington’s chorea.
Which choreography the distinct steps follow is not sufficiently known. Furthermore, the correlation between structure and function is determined only for a few proteins. Peter Wolynes pursues the question with considerations from physics, especially on the basis of energy dynamics: the protein passes through stable states on its way to an energetic minimum, so that protein folding forms a complex energy landscape. In the scientific literature, this is called Energy Landscape Theory (ELT). The theory also helps to better understand why some proteins fold quickly and precisely but others fold slowly and are prone to error.
He also developed another metaphor that describes protein folding as a funnel: the “funnel landscape”. Amongst the numerous others possible ways of folding, a primary way that leads to an energetic minimum crystallises.
Peter Wolynes is not only concerned with protein folding, but also with the open questions of cellular biology that he views from a novel position. Further areas of his interest reach from the question how loosely arranged strains of DNA are packed into chromosomes to the long-term retention of memories.
He applies the concept of the energetic landscape to glass transition of molecular fluids, which describes the transition of a material from a solid, rigid state into a viscoelastic or rubber-like state. This transition is characterised by a certain temperature at which the material loses its crystalline structures and becomes amorphous.
Glass transition occurs in a variety of materials, including plastics, rubbers, lacquers, and glasses and depends both on the material itself as well as on external factors, such as pressure and moisture. Today, glass transition is part of the more general “Random First Order Transition Theory (RFOT)”
Peter Wolynes‘ perspective on biological problems and questions of material science not only generated new hypotheses, but also paved the way for new methods in application. With that, he contributed to a deeper understanding of biological processes, as well as to the dynamic behaviour of various materials. His findings in protein dynamics also bear the potential to develop new ways of treating diseases that that are based on defectively folded proteins.