Vortrag: Characterization of regulatory small RNAs and RNA-binding proteins
- Vorträge & Diskussionen
- Hörsaal des Leibniz-Instituts für Agrarentwicklung in Mittel- und Osteuropa (IAMO), Theodor-Lieser-Str. 2, Halle (Saale)
Referent: Prof. Dr. Thomas Tuschl, Rockefeller University, New York, USA
- Datum
- Ort Hörsaal des Leibniz-Instituts für Agrarentwicklung in Mittel- und Osteuropa (IAMO), Theodor-Lieser-Str. 2, Halle (Saale)
Prof. Tuschl studies how RNA-binding proteins (RBPs) and small-RNA-containing ribonucleoprotein complexes (RNPs) regulate messenger RNAs (mRNAs) in human cells. The lab develops experimental approaches to precisely define the RNA recognition elements (RREs) bound by RBPs and RNPs and examine their regulatory function at a transcriptome level. Current studies focus on characterizing RBPs that control mRNA stability or where mutations cause genetic diseases, such as fragile X syndrome and amyotrophic lateral sclerosis. The identification of posttranscriptional regulatory networks will increase our understanding of the molecular causes of disease and may lead to the rational design of new therapeutic agents. Finally, we are establishing a platform for discovery and use of RNA as a biomarker by recording and quantifying alteration in transcript isoforms and their abundance in normal and disease conditions using deep sequencing followed by RNA fluorescence in situ hybridization in large pathological tissue collections. Eine Anmeldung ist nicht erforderlich. Eine Anfahrtsbeschreibung finden Sie hier:
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