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Prof. Dr.

Horst Malke

Year of election: 1999
Section: Microbiology and Immunology
City: Jena
Country: Germany
CV Horst Malke - English (PDF)
List of Publications (PDF)

Research

Horst Malke is primarily recognized for many contributions to the genetics of bacteria, particularly the pathogenic streptococci. He developed novel transduction and conjugation systems for genetic exchange that served as freely available tools for the genetic analysis of streptococci in the pre-recombinant DNA era. Teaming up with researchers at OUHSC, he was the first to clone, sequence, ectopically express and comprehensively characterize the polymorphic streptokinase gene, the product of which is exploited as a fibrinolytic agent in clinical medicine.

His current work includes seminal discoveries involving global streptococcal transcription regulators (relA and codY) that sense the nutritional status of the bacterial cell in the integration of metabolic and virulence pathways. 

Career

  • since 2009 Affiliate Professor of Research, Oklahoma University Health Sciences Center (OUHSC), Oklahoma City, USA
  • 2003-2008 Professor of Research, OUHSC, USA
  • 1999-2002 Director, Institute of Molecular Biology, Faculty of Biology and Pharmacy, Friedrich Schiller University (FSU), Jena, Germany
  • 1993-2002 Professorial Chair of Molecular Genetics, FSU Jena, Germany
  • 1992 Group Leader, University Revival Program, Federal Republic of Germany
  • 1987 Appointment as Professor of Genetics, Academy of Sciences of the GDR
  • 1984-1991 Head, Department of Molecular Genetics, Central Institute of Microbiology and Experimental Therapy (ZIMET) of the Academy of Sciences of the GDR, Jena, Germany
  • 1973-1983 Head, Research Group for Streptococcal Genetics, ZIMET Jena, Germany
  • 1966-1972 Head-Assistant, Department of Medical Microbiology, ZIMET Jena, Germany
  • 1972 Habilitation (Dr.rer.nat.habil.), Ernst Moritz Arndt University (EMAU) Greifswald, Germany
  • 1965 Ph.D., EMAU Greifswald, Germany
  • 1963-1965 Fellow, Institute of Microbiology, EMAU Greifswald, Germany
  • 1962 Postgraduate Course for Microbiology (1 year), German Academy of Sciences, Institute of Microbiology and Experimental Therapy (IMET), Jena, Germany
  • 1960-1961 Scientific Assistant, Institute of Botany, College of Education, Potsdam, Germany
  • 1955-1960 Student of Biology (Major) and Chemistry (Minor), College of Education, Potsdam, Germany

Projects

  • 2004-2009 Principal Investigator of the project “Response of Streptococcus pyogenes to nutritional stress“ sponsored by grant AI054473-01A2 from the National Institutes of Health (NIH), Bethesda, USA
  • 2001-2002 Member, consortium of principal investigators of the Germany-wide “PathoGenoMics Network“ sponsored by the Federal Ministry of Education and Research (BMBF)
  • 1999-2002 Principal Investigator of the project „Expression control of virulence genes of pathogenic streptococci mediated by extracellular and intracellular signal molecules“ sponsored by the German Research Association (DFG); Co-Investigator (with Rolf Hilgenfeld) of the project “Genetics, enzymology, and structural basis of metabolism control by guanosine polyphosphates“ sponsored by the DFG
  • 1996-1998 Principal Investigator of the project “Structural and functional analysis of bacterial cytoplasmic membrane proteins, in particular lipoprotein and phosphatases“ sponsored by the Thuringian Ministry of Science, Research and Arts (TMWFK)
  • 1992-2002 Principal Investigator of the long-term project served to improve the infrastructural basis of research in the new Länder of Germany, sponsored by the Fonds of the Chemical Industry (FCI)
  • 1991-1998 Principal Investigator of the project “Molecular genetic analysis of the chromosomal streptokinase gene region of pathogenic streptococci“ sponsored by the DFG

Functions

  • 1994-2002 Member, International Advisory Committee for the Streptococcus pyogenes Genome Sequencing Project at the University of Oklahoma, USA
  • 1993-2002 Member, American Society for Microbiology (ASM)
  • 1989-2006 Member, Advisory Board of the „Zentralblatt füt Bakteriologie“, Gustav Fischer Verlag, Stuttgart and New York and the “International Journal of Medical Microbiology“, Elsevier GmbH, respectively. Ad hoc reviewer of diverse professional journals, including “Molecular and General Genetics“, “Molecular Microbiology“, “Journal of Bacteriology“, and “Public Library of Science“ (PLoS)
  • 1985-2008 Editor-in-Chief, ”Journal of Basic Microbiology“, Akademie-Verlag Berlin and Wiley VCH Verlag GmbH, Weinheim, respectively, Germany
  • 1979-1990 Member, “Commission for work on in-vitro recombination of DNA“, Ministry of Health of the GDR
  • 1978-1982 Member, Scientific Advisory Board of the “Main Research Initiative in influenza and other infectious diseases, including streptococcal research“ of the Research Association for Immunology and Infectious Diseases sponsored by the Ministry of Health of the GDR
  • 1970-1981 Chairman of the Group for Microbial Genetics of the “Society for General and Technical Microbiology“ of the GDR

Honours and Memberships

  • since 2008 Honorary Editor, Journal of Basic Microbiology, Wiley-VCH Verlag GmbH, Weinheim, Germany
  • 2002 University of Oklahoma Science Recognition and Achievement Award for “Pioneering Work in the Genetics and Molecular Biology of Pathogenic Streptococci, Outstanding Original Scientific Contributions to the Understanding of Infectious Diseases and Public Health, Training of Future Leaders in Their Field, Dedication to International Cooperation and World Health”, USA
  • since 1999 Member of the National Academy of Sciences Leopoldina, Germany
  • since 1997 Member, „Akademie gemeinnütziger Wissenschaften zu Erfurt“, Germany
  • 1983-1990 Visiting Scientist Awardee and Visiting Professor, respectively, under the sponsorship of Joseph J. Ferretti, OUHSC, Department of Microbiology and Immunology, Oklahoma City, USA
  • 1980-1981 Visiting Scientist Awardee under the sponsorship of Stig E. Holm, University of Umea, Department of Clinical Bacteriology, Umea, Sweden
  • 1976-1977 Career Investigator Visiting Scientist Awardee of the American Heart Association under the sponsorship of Lewis W. Wannamaker, Department of Pediatrics and Microbiology, University of Minnesota, Minneapolis, USA
  • 1974 Rudolf Virchow Prize for work on the “Genetics of pathogenic bacteria, in particular streptococci“; Ministry of Health, GDR

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