|Year of election:||2006|
|Section:||Microbiology and Immunology|
CV Michael Reth - Englisch (PDF)
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My group works on differentiation and activation mechanisms of B lymphocytes of the mammalian immune system. Our work resulted in a better description of the B cell antigen receptor and we discovered several critical signal elements in B lymphocytes. Since 1998 we are applying synthetic biology approaches for a better study of signaling processes in lymphocytes. With this approach we made several key discoveries that resulted in a new hypothesis for B cell activation, namely the dissociation-activation model (DAM). In our signaling studies we are currently combining biochemical, genetic, molecular biology and synthetic biology techniques. We also have developed a modification of the proximity ligation assay (PLA) which allows us to study the molecular interactions around receptors of lymphocytes at the 10-20 nanometer range. With this technique we discover a new world of nanoscale molecular interaction in and at the membrane and open a venue to the field of Nanobiology.
06108 Halle (Saale)
|Phone||0345 - 47 239 - 122|
|Fax||0345 - 47 239 - 139|