The widespread availability of antiviral drugs that can be used in addition to prophylactic vaccines in the event of a pandemic is a key component of effective pandemic preparedness. Experience with the COVID-19 pandemic has shown the world’s lack of preparedness for emerging pathogens with pandemic potential. Urgent action is therefore needed to develop new antiviral drugs. The G7 Academies call for fostering the discovery and development of specific and broad-spectrum antiviral drugs by providing long-term funding, building adequate infrastructures for efficient clinical studies, and promoting the international coordination in the field of pandemic preparedness.