International sources of tension are causing increasing social pressure and exacerbating the crises caused by the pandemic and climate change. In order to be prepared for future pandemics, ensure sustainable food security for the world’s growing population, or preserve humanity’s cultural heritage, multilateral collaboration is essential. The science academies of the G7 states published six statements with proposed courses of action regarding pressing global challenges. The academies call upon the G7 states to address the topics of agriculture, artificial intelligence, cultural heritage, health, nuclear arms control, and social inequalities at this year’s G7 summit in Apulia, Italy. The statements were written under the direction of the Italian Accademia Nazionale dei Lincei with the involvement of the German National Academy of Sciences Leopoldina.