The One Health approach is a multisectoral and transdisciplinary approach, based on the understanding that the health of humans, domestic and wild animals, plants and the wider environment is closely linked and interdependent. The disruption of global ecosystems fosters the emergence of human pathogens from animal populations and vice versa (“zoonotic diseases”). Furthermore, the most effective means to treat infectious diseases, namely antimicrobial drugs (e.g. antibiotics), is losing effectiveness due to increasing antimicrobial resistance (AMR). In order to address these global problems, the G7 Academies call for concrete actions to implement the One Health approach globally, the use of new digital technologies for the prevention and control of zoonotic diseases and AMR, and fostering research and development focused on One Health.