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Foto: Myra Klarman
|Sektion:||Biochemie und Biophysik|
|Stadt:||Ann Arbor, MI|
Research Priorities: Oxidative Stress, Redox Regulation, Aging, Age-Related Diseases, Proteostasis
Ursula Jakob is a biologist working in the fields of biochemistry and biophysics. Her research focuses on stress-related processes such as stress defense pathways in bacteria, which can be exploited for more effective antimicrobial therapies. She investigates how transient stress events experienced early in life can extend lifespan and protect organisms against age-associated diseases.
The major research focus of her lab is to understand how organisms respond to naturally occurring stress conditions, particularly elevated temperatures and increased levels of reactive oxygen species (ROS). One specific goal is to identify bacterial and parasitic proteins that sense and respond to these host-elicited stress conditions by altering gene expression and activating stress-specific chaperone. A better understanding of the bacterial defense mechanisms could help to develop strategies to increase the sensitivity of bacteria towards the innate immune defense of the host and to identify novel drug targets as well as to enhance the efficacy of established antibiotics.
A second major research avenue concerns the role of physiologically occurring ROS variations in aging and age-related diseases, including Alzheimer’s Disease and Parkinson’s Disease. These studies are based on the finding that ROS, which are produced in response to metabolic, hormonal and other cues, are effective signaling molecules affecting multiple metabolic processes involved in cell growth, differentiation and proliferation.
Her research showed that natural variations of ROS, particularly during early development, can have profound, long-lasting and, most importantly, beneficial effects on lifespan and age-associated diseases. Her lab discovered the underlying mechanism by demonstrating that the epigenetic landscape is redox controlled, and early ROS accumulation causes persistent and potentially transgenerational long-term consequences.
06108 Halle (Saale)
|Tel.||0345 - 47 239 - 120|
|Fax||0345 - 47 239 - 139|