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Foto: Myra Klarman

Prof. Dr.

Ursula Jakob

Wahljahr: 2020
Sektion: Biochemie und Biophysik
Stadt: Ann Arbor, MI
Land: USA
CV Ursula Jakob - English (PDF)

Forschung

Research Priorities: Oxidative Stress, Redox Regulation, Aging, Age-Related Diseases, Proteostasis

Ursula Jakob is a biologist working in the fields of biochemistry and biophysics. Her research focuses on stress-related processes such as stress defense pathways in bacteria, which can be exploited for more effective antimicrobial therapies. She investigates how transient stress events experienced early in life can extend lifespan and protect organisms against age-associated diseases.

The major research focus of her lab is to understand how organisms respond to naturally occurring stress conditions, particularly elevated temperatures and increased levels of reactive oxygen species (ROS). One specific goal is to identify bacterial and parasitic proteins that sense and respond to these host-elicited stress conditions by altering gene expression and activating stress-specific chaperone. A better understanding of the bacterial defense mechanisms could help to develop strategies to increase the sensitivity of bacteria towards the innate immune defense of the host and to identify novel drug targets as well as to enhance the efficacy of established antibiotics.

A second major research avenue concerns the role of physiologically occurring ROS variations in aging and age-related diseases, including Alzheimer’s Disease and Parkinson’s Disease. These studies are based on the finding that ROS, which are produced in response to metabolic, hormonal and other cues, are effective signaling molecules affecting multiple metabolic processes involved in cell growth, differentiation and proliferation.

Her research showed that natural variations of ROS, particularly during early development, can have profound, long-lasting and, most importantly, beneficial effects on lifespan and age-associated diseases. Her lab discovered the underlying mechanism by demonstrating that the epigenetic landscape is redox controlled, and early ROS accumulation causes persistent and potentially transgenerational long-term consequences.

Werdegang

  • since 2014 Collegiate Professor, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, USA
  • since 2012 Professor, University of Michigan Medical School, Department of Biological Chemistry, Ann Arbor, USA
  • since 2011 Professor, University of Michigan, Department of Molecular, Cellular and Developmental Biology, Ann Arbor, USA
  • 2010-2012 Associate Professor, University of Michigan, Medical School, Department of Biological Chemistry, Ann Arbor, USA
  • 2007-2011 Associate Professor, University of Michigan, Department of Molecular, Cellular and Developmental Biology, Ann Arbor, USA
  • 2001-2007 Assistant Professor, University of Michigan, Department of Molecular, Cellular and Developmental Biology, Ann Arbor, USA
  • 1999-2001 Assistant Research Scientist (lab of James Bardwell), University of Michigan, Department of Biology Ann Arbor, USA
  • 1996-1998 DFG-sponsored Postdoctoral Fellow (lab of James Bardwell), University of Michigan, Department of Biology, Ann Arbor, USA
  • 1995 Ph.D. awarded with summa cum laude
  • 1992 Visiting Scientist (lab of C.T. Walsh), Harvard Medical School, Boston, USA
  • 1991-1995 Ph.D. student, University of Regensburg, Regensburg, Biophysics and Physical Biochemistry Department (lab of J. Buchner, Dept. of R. Jaenicke), Germany
  • 1990-1991 Visiting Scientist (lab of R. Zimmermann), Ludwig-Maximilians-Universität München, Munich, Germany
  • 1986-1991 Diplom (equivalent to M.S.) in Biology, University of Regensburg, Germany

Funktionen

  • 2017-2022 Associate Editor, The Journal of Biological Chemistry
  • 2014-2018 Advisory Board Member, Protein Folding Disease Initiative, USA
  • 2013-2017 Member of the Membrane Biology and Protein Processing Study (MBPP), National Institutes of Health (NIH), USA

Projekte

  • 2017-2022 Principal Investigator, "Role of Molecular Chaperones in Stress Response and Disease", National Institute of Health
  • 2019-2022 Principal Investigator, "Role of early epigenetic events in stress resistance and lifespan", Glenn/AFAR Breakthroughs in Gerontology (BIG) Award 2019
  • 2014-2020 Co Principal Investigator, "Role of Get3 as Redox-Regulated Chaperone", DFG-Project (German Research Foundation)
  • 2015-2019 Principal Investigator, "Polyphosphate - A Novel Member of the Proteostasis Network", National Institutes of Health (NIH), USA
  • 2013-2018 Co-Principal Investigator, "Mechanism of an Acid Activated Chaperone", National Institutes of Health (NIH), USA
  • 2003-2017 Principal Investigator, "Functional Analysis of the Intrinsically Disordered Chaperone Hsp33", National Institutes of Health (NIH), USA
  • 2007-2012 "Oxidative Protein Thiol Modifications and Aging", National Institute on Aging, USA
  • 2000-2005 Principal Investigator, Burroughs Wellcome Fund Career Award in Biomedical Sciences, USA

Auszeichnungen und Mitgliedschaften

  • since 2020 Fellow of the American Association for the Advancement of Science
  • since 2020 Member of the German National Academy of the Sciences Leopoldina
  • 2019 Breakthrough in Gerontology Award
  • 2014 Member of the Bavarian Academy of the Sciences and Humanities
  • 2011 Faculty Recognition Award
  • 2000 Burroughs Wellcome Fund Career Award in Biomedical Sciences
  • 2001 Biological Scholar Award from the University of Michigan
  • 1998 Sokol Postdoctoral Award
  • 1996 Postdoctoral Fellowship, German Research Foundation (DFG)
  • 1992 Ph.D. Scholarship, Academic Foundation of the German People

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